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10 p, 391.9 KB |
Ponesimod Compared with Teriflunomide in Patients with Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study : A Randomized Clinical Trial
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Kappos, Ludwig (University of Basel) ;
Fox, Robert J. (Cleveland Clinic) ;
Burcklen, Michel (Actelion Pharmaceuticals) ;
Freedman, Mark S. (University of Ottawa) ;
Kubala Havrdova, Eva (Charles University) ;
Hennessy, Brian (Actelion Pharmaceuticals) ;
Hohlfeld, Reinhard (Ludwig Maximilians University Munich) ;
Lublin, Fred (Icahn School of Medicine at Mount Sinai) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Pozzilli, Carlo (Sapienza University of Rome) ;
Scherz, Tatiana (Actelion Pharmaceuticals) ;
D'Ambrosio, Daniele (Galapagos GmbH) ;
Linscheid, Philippe (Actelion Pharmaceuticals) ;
Vaclavkova, Andrea (Actelion Pharmaceuticals) ;
Pirozek-Lawniczek, Magdalena (Actelion Pharmaceuticals) ;
Kracker, Hilke (Actelion Pharmaceuticals) ;
Sprenger, Till (University of Basel) ;
Universitat Autònoma de Barcelona
Importance: To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease-modifying therapies for relapsing multiple sclerosis (RMS). [...]
2021 -  10.1001/jamaneurol.2021.0405
JAMA Neurology, Vol. 78 Núm. 5 (may 2021) , p. 558-567
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10 p, 509.3 KB |
Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
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Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis. What are the long-term outcomes of patients developing progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis? In this longitudinal cohort study including 1128 patients with a first demyelinating event in multiple sclerosis, presenting with PIRA was associated with significantly shorter times to developing severe disability compared with not presenting with PIRA. [...]
2022 - 10.1001/jamaneurol.2022.4655
JAMA Neurology, Vol. 80 (december 2022) , p. 151-160
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11 p, 1.6 MB |
Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia
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Friedberg, Adit (Global Brain Health Institute, University of California, San Francisco, and Trinity College Dublin, Dublin, Ireland) ;
Pasquini, Lorenzo (Neuroscape, University of California, San Francisco) ;
Diggs, Ryan (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Glaubitz, Erika A. (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Lopez, Lucia (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Illán-Gala, Ignacio (Institut de Recerca Sant Pau) ;
Iaccarino, Leonardo (now with Eli Lilly and Company, Philadelphia, Pennsylvania) ;
La Joie, Renaud (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Mundada, Nidhi (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Knudtson, Marguerite (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Neylan, Kyra (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Brown, Jesse (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Allen, Isabel (Global Brain Health Institute, University of California, San Francisco, and Trinity College Dublin, Dublin, Ireland) ;
Rankin, Katherine P. (Global Brain Health Institute, University of California, San Francisco, and Trinity College Dublin, Dublin, Ireland) ;
Bonham, Luke W. (Department of Radiology and Biomedical Imaging, University of California, San Francisco) ;
Yokoyama, Jennifer S. (Department of Radiology and Biomedical Imaging, University of California, San Francisco) ;
Ramos, Eliana M. (Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles) ;
Geschwind, Daniel H. (Institute for Precision Health, University of California, Los Angeles) ;
Spina, Salvatore (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Grinberg, Lea T. (Department of Pathology, University of California, San Francisco) ;
Miller, Zachary A. (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Kramer, Joel H. (University of California. Department of Neurology) ;
Rosen, Howard (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Gorno-Tempini, Maria Luisa (Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco) ;
Rabinovici, Gil (Associate Editor, JAMA Neurology) ;
Seeley, William W. (Department of Pathology, University of California, San Francisco) ;
Miller, Bruce L. (Global Brain Health Institute, University of California, San Francisco, and Trinity College Dublin, Dublin, Ireland) ;
Universitat Autònoma de Barcelona
This case-control study assesses the anatomical and physiological underpinnings of visual artistic creativity in individuals with frontotemporal dementia. What are the neural underpinnings of visual artistic creativity (VAC) in the setting of frontotemporal dementia (FTD)? In this study of 119 patients, VAC occurred early in the course of FTD, was disproportionately observed in patients with temporal lobe-predominant degeneration, and may be associated with damage to brain regions that normally suppress dorsomedial occipital cortex function. [...]
2023 - 10.1001/jamaneurol.2023.0001
JAMA Neurology, Vol. 80 (february 2023) , p. 377-387
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8 p, 351.8 KB |
Efficacy and Safety of Ticagrelor and Aspirin in Patients with Moderate Ischemic Stroke : An Exploratory Analysis of the THALES Randomized Clinical Trial
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Wang, Yongjun (China National Clinical Research Center for Neurological Diseases) ;
Pan, Yuesong (China National Clinical Research Center for Neurological Diseases) ;
Li, Hao (China National Clinical Research Center for Neurological Diseases) ;
Amarenco, Pierre (University of Paris) ;
Denison, Hans (AstraZeneca) ;
Evans, Scott R. (George Washington University) ;
Himmelmann, Anders (AstraZeneca) ;
James, Stefan (Uppsala University) ;
Birve, Filip (AstraZeneca) ;
Ladenvall, Per (AstraZeneca) ;
Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ;
Johnston, S. Claiborne (University of Texas at Austin) ;
Universitat Autònoma de Barcelona
Importance: Prior trials of dual antiplatelet therapy excluded patients with moderate ischemic stroke. These patients were included in the Acute Stroke or Transient Ischaemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death (THALES) trial, but results have not been reported separately, raising concerns about safety and efficacy in this subgroup. [...]
2021 - 10.1001/jamaneurol.2021.2440
JAMA Neurology, Vol. 78 Núm. 9 (september 2021) , p. 1091-1098
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11 p, 1.6 MB |
Association of Apolipoprotein e ϵ4 Allele with Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults with down Syndrome
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Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Videla Toro, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez, S. (Universitat Autònoma de Barcelona) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Giménez, Sandra (Institut d'Investigació Biomèdica Sant Pau) ;
González-Ortiz, Sofía (Hospital del Mar (Barcelona, Catalunya)) ;
Muñoz, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Padilla, Concepción (Institut d'Investigació Biomèdica Sant Pau) ;
Aranha, Mateus (Institut d'Investigació Biomèdica Sant Pau) ;
Estellés, T. (Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED)) ;
Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ;
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ;
Wilson, L.R. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge. Douglas House) ;
Annus, Tiina (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge. Douglas House) ;
Osorio, R.S. (Healthy Brain Aging and Sleep Center. Department of Psychiatry. New York University. Grossman School of Medicine) ;
Videla, S. (Institut d'Investigació Biomèdica de Bellvitge) ;
Lehmann, S. (Le Laboratoire de Biochimie et Protéomique Clinique. Université Montpellier. Centre Hospitalier Universitaire Montpellier. Institut National de la Santé et de la Recherche Médicale) ;
Holland, Anthony (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge. Douglas House) ;
Zetterberg, Henrik (Department of Neurodegenerative Disease. UCL Queen Square Institute of Neurology) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Zaman, S.H. (Cambridgeshire and Peterborough National Health Service (NHS) Foundation Trust. Fulbourn Hospital. Elizabeth House) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Importance: Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Previous studies have suggested that the APOE ϵ4 allele plays a role in the risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce. [...]
2021 - 10.1001/jamaneurol.2021.1893
JAMA Neurology, Vol. 78 Núm. 8 (august 2021) , p. 937-947
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12 p, 544.9 KB |
Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis
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Marini, Sandro (Massachusetts General Hospital (Boston)) ;
Crawford, Katherine (Massachusetts General Hospital (Boston)) ;
Morotti, A. (Fondazione Mondino IRCCS, Pavia) ;
Lee, M. J. (Massachusetts General Hospital (Boston)) ;
Pezzini, Alessandro (Università degli Studi di Brescia) ;
Moomaw, C. J. (University of Cincinnati) ;
Flaherty, M. L. (University of Cincinnati) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tarraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Slowik, A. (Jagiellonian University Medical College, Kraków) ;
Jagiella, Jeremiasz M (Jagiellonian University Medical College, Kraków) ;
Pera, J. (Jagiellonian University Medical College, Kraków) ;
Urbanik, Andrzej (Jagiellonian University Medical College, Kraków) ;
Pichler, A. (Jagiellonian University Medical College, Kraków) ;
Hansen, Björn M (Lund University) ;
McCauley, J. L. (John P. Hussman Institute for Human Genomics, Miami) ;
Tirschwell, D. L. (University of Washington) ;
Selim, Magdy (Beth Israel Deaconess Medical Center, Boston) ;
Brown, D. L. (University of Michigan) ;
Silliman, Scott L. (University of Florida College of Medicine) ;
Worrall, B. B. (University of Virginia Health System) ;
Meschia, J. F. (Mayo Clinic, Jacksonville, Florida) ;
Kidwell, C. S. (University of Arizona) ;
Testai, F. D. (University of Illinois) ;
Kittner, S. J. (University of Maryland School of Medicine) ;
Schmidt, H. (Medical University of Graz) ;
Enzinger, C. (Medical University of Graz) ;
Deary, Ian J. (University of Edinburgh) ;
Rannikmae, K. (University of Edinburgh) ;
Samarasekera, N. (University of Edinburgh) ;
Salman, R. A. S. (University of Edinburgh) ;
Sudlow, C. L. (University of Edinburgh) ;
Klijn, C. J. M. (UMC Utrecht Brain Center Rudolf Magnus) ;
Van Nieuwenhuizen, K. M. (UMC Utrecht Brain Center Rudolf Magnus) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Norrving, B. (Lund University) ;
Lindgren, A. (Lund University) ;
Goldstein, J. N. (Massachusetts General Hospital (Boston)) ;
Viswanathan, Anand (Massachusetts General Hospital (Boston)) ;
Greenberg, S. M. (Massachusetts General Hospital (Boston)) ;
Falcone, G. J. (Yale University) ;
Biffi, Alessandro (Massachusetts General Hospital (Boston)) ;
Langefeld, Carl D (Wake Forest University, Winston-Salem, North Carolina) ;
Woo, D. (University of Cincinnati College of Medicine) ;
Rosand, J. (Massachusetts General Hospital (Boston)) ;
Anderson, C. D. (Massachusetts General Hospital (Boston)) ;
Universitat Autònoma de Barcelona
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. [...]
2019 - 10.1001/jamaneurol.2018.4519
JAMA Neurology, Vol. 76 Núm. 4 (april 2019) , p. 480-491
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